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Antral follicle
An antral follicle (or secondary follicle) is an ovarian follicle during a certain latter stage of folliculogenesis.
Definitions differ in where the shift into an antral follicle occurs in the staging of folliculogenesis, with some stating that it occurs when entering the ''secondary'' stage,〔(Page 769 ), section "formation of the antrum" in: 〕 and others stating that it occurs when entering the ''tertiary'' stage.〔Page 76 in: 〕
==Appearance==
It is marked by the formation of a fluid-filled cavity adjacent to the oocyte called the antrum. The basic structure of the mature follicle has formed and no novel cells are detectable. Granulosa and theca cells continue to undergo mitosis concomitant with an increase in antrum volume. Antral follicles can attain a tremendous size that is hampered only by the availability of follicle stimulating hormone (FSH), which it is dependent on in this stage of folliculogenesis.
By command of an oocyte-secreted morphogenic gradient, the antral follicle's granulosa cells begin to differentiate themselves into four distinct subtypes: ''corona radiata'' that surrounds the zona pellucida, ''membrana'' that's interior to the basal lamina, ''periantral'' that's adjacent to the antrum, and ''cumulus oophorus'' that connects the membrana and corona radiata granulosa cells together. Each type of cell behaves differently in response to FSH.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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